{"protein": {"Protein ID": "WNK3_ENST00000375159", "UniProt Accession": "Q9BYP7", "Gene Name": "WNK3", "Name": "Serine/threonine-protein kinase WNK3", "Transcript ID": "ENST00000375159.6", "Chromosome": "chrX", "Cancer Driver": "Not Cancer Driver"}, "exon": [{"exon_number": 7, "start": 467, "end": 565}], "phastcons": ["1.0", "0.485", "1.0", "1.0", "0.996", "1.0", "0.8420000000000001", "1.0", "1.0", "1.0", "0.9975", "0.7795000000000001", "1.0", "1.0"], "complexity-seg": null, "complexity-dust": null, "complexity-trf": null, "polymorphism": [{"Mutation": "E540E", "Type": "All"}, {"Mutation": "H546Y", "Type": "All"}, {"Mutation": "Q550L", "Type": "All"}, {"Mutation": "R548K", "Type": "All"}, {"Mutation": "H546R", "Type": "All"}, {"Mutation": "Q550H", "Type": "All"}, {"Mutation": "Q550Q", "Type": "All"}, {"Mutation": "V543A", "Type": "All"}], "omim": null, "clinvar": null, "pdb": {"5NKPD": ["5NKPD 0 ord 536 545 0  100", "5NKPD 1 dis 546 546 0  100"]}, "pfam": null, "Disordered": {"combined": ["4", "4", "4", "4", "4", "4", "4", "4", "4", "4", "4", "4", "4", "4"], "anchor": null, "iupred": ["0.6919", "0.6998", "0.6919", "0.686", "0.6564", "0.628", "0.6131", "0.6029", "0.6116", "0.6215", "0.6351", "0.6537", "0.6618", "0.6525"], "mobidb": null, "alphafold": null}, "tcgam": {"mutations": {"E537D": 1, "E537G": 1, "T541A": 1, "V543F": 1}, "cancertypes": {"COAD": 1, "KIRC": 1, "LGG": 1, "OV": 1}}, "tcgaf": null, "tcgai": null, "cosmicm": {"mutations": {"D544N": 1, "E537A": 1, "E537D": 1, "E537G": 1, "T541A": 1, "V543F": 1}, "cancertypes": {"COAD": 1, "KIRC": 1, "LGG": 1, "OV": 1, "UCEC": 2}}, "cosmicf": null, "cosmici": null, "roisig": null, "elm": [{"id": 5444, "protein_id": "WNK3_ENST00000375159", "ELM_Accession": "ELMI002836", "ELMType": "DEG", "ELMIdentifier": "DEG_Kelch_KLHL3_1", "Start": 537, "End": 546, "References": "23838290", "Methods": "coimmunoprecipitation; fluorescence polarization spectroscopy", "InstanceLogic": "true positive", "PDB": "nan", "Organism": "Homo sapiens"}], "scansite": null, "elmswitches": null, "ptm": [{"Position": 541, "Type": "Phosphorylation", "Database": "Phophositeplus"}], "roi": null, "binding": null, "dibs": null, "mfib": null, "binding_domain": null, "phasepro": null, "conservation": {"global": ["0.071", "0.083", "0.086", "0.075", "0.092", "0.154", "0.173", "0.199", "0.273", "0.179", "0.199", "0.093", "0.114", "0.173"], "Mammalia": ["0.742", "0.724", "0.801", "0.761", "0.745", "0.797", "0.749", "0.716", "0.79", "0.675", "0.746", "0.663", "0.71", "0.764"], "Vertebrata": ["0.0", "0.0", "0.0", "0.0", "0.0", "0.087", "0.096", "0.099", "0.089", "0.1", "0.052", "0.001", "0.0", "0.0"], "Eumetazoa": ["0.005", "0.015", "0.013", "0.009", "0.031", "0.057", "0.081", "0.14", "0.165", "0.133", "0.113", "0.029", "0.06", "0.119"], "Eukaryota": ["0.0", "0.0", "0.0", "0.0", "0.002", "0.37", "0.464", "0.322", "0.32", "0.016", "0.014", "0.013", "0.013", "0.013"]}}